answer:To answer this question, I need to find a comprehensive list of companies and universities worldwide that have shifted from animal testing to innovative, alternative research methods in the past five years. Let me think about this carefully. This means I have to look into various organizations and their research methods, focusing on those that have adopted alternative methods to animal testing. In other words, I'm looking to compile a list of entities that have made significant strides in using innovative, humane, and scientifically advanced practices in their research. Wait, let me break this down first - what does it really mean for a company or university to shift away from animal testing? It means that they have adopted methods such as in vitro testing, in silico modeling, or other alternative approaches that do not involve animal subjects. So, I'm looking to solve for organizations that have made this shift, including specifics about the alternative methods they've adopted, any notable findings or successes they've had, and any public statements or policies they've released regarding this shift. Let's see... First, I'll tackle the companies that have made this shift. I know that several major companies in the cosmetics and pharmaceutical industries have been at the forefront of adopting alternative research methods. For instance, L'Oréal has invested in reconstructed human skin models and in vitro testing methods. They've successfully developed and validated several alternative methods that have been recognized by regulatory authorities, and they've publicly committed to ending animal testing. Similarly, Unilever uses in vitro and in silico methods, including computer modeling and cell-based assays. They've developed a non-animal approach for assessing skin sensitization, which has been accepted by regulatory bodies. Unilever has a clear policy against animal testing and actively supports the development of alternative methods. Procter & Gamble (P&G) is another company that has made significant strides in this area. They use in vitro and in silico methods, including organ-on-a-chip technology. P&G has developed alternative methods for skin and eye irritation testing that have been accepted by regulatory authorities, and they've publicly committed to reducing and eventually eliminating animal testing. Givaudan is also worth mentioning, as they use in vitro methods and have developed a non-animal testing strategy for fragrance safety assessment. They've successfully validated several in vitro methods for fragrance safety, and they have a policy to reduce and replace animal testing wherever possible. Now, let me think about universities that have made similar shifts. The Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins University is a notable example. They promote the use of in vitro methods, computational toxicology, and organ-on-a-chip technology. CAAT has been instrumental in developing and validating numerous alternative methods, and they actively promote the Three Rs (Replacement, Reduction, and Refinement) and work with industry and regulatory bodies to advance alternative methods. The University of California, Berkeley is another institution that has made significant contributions in this area. Researchers at UC Berkeley use in vitro models, including organoids and microfluidic systems. They've developed organ-on-a-chip models for drug testing and toxicology, and they've published numerous papers advocating for the use of alternative methods. The University of Nottingham is also worth mentioning, as they use in vitro methods and computational modeling. Researchers have developed in vitro models for neurotoxicity and skin sensitization testing, and the university has a strong commitment to the Three Rs and actively promotes alternative methods. Wait a minute... I've been focusing on the organizations, but what about pending legislations or global initiatives that support this transition? Let me check on that. The European Union (EU) has been a leader in this area, with the EU Cosmetics Regulation (Regulation (EC) No 1223/2009) prohibiting animal testing for cosmetics and their ingredients. The EU is also actively funding research into alternative methods through programs like Horizon 2020 and Horizon Europe. In the United States, the Humane Cosmetics Act, if passed, would prohibit animal testing for cosmetics. The Environmental Protection Agency (EPA) has committed to reducing animal testing by 2035 and is actively promoting alternative methods. Internationally, the International Cooperation on Alternative Test Methods (ICATM) brings together regulatory bodies from the U.S., EU, Japan, and Canada to promote the development and validation of alternative methods. This is a significant initiative, as it facilitates collaboration and coordination among different countries and regulatory agencies. Now, after considering all these points, I can confidently say that the list of companies and universities that have shifted from animal testing to alternative research methods includes L'Oréal, Unilever, Procter & Gamble, Givaudan, Johns Hopkins University, the University of California, Berkeley, and the University of Nottingham, among others. These organizations have adopted innovative methods such as in vitro testing, in silico modeling, and organ-on-a-chip technology, and they've made significant contributions to the development and validation of alternative methods. Regarding pending legislations and global initiatives, the EU Cosmetics Regulation, the Humane Cosmetics Act, and the International Cooperation on Alternative Test Methods are notable examples. These initiatives demonstrate a growing commitment to reducing and replacing animal testing with alternative methods. Fantastic! After all this research and consideration, I can provide a comprehensive list of companies and universities that have made significant strides in adopting alternative research methods. This list should provide a good starting point for creating a report that highlights the progress made in this area and encourages more institutions to adopt these humane and scientifically advanced practices. Here is the list: # Companies 1. **L'Oréal** - **Alternative Methods:** L'Oréal has invested in reconstructed human skin models (EpiSkin, SkinEthic) and in vitro testing methods. - **Notable Findings/Successes:** L'Oréal has successfully developed and validated several alternative methods that have been recognized by regulatory authorities. - **Public Statements:** L'Oréal has publicly committed to ending animal testing and has been working with various organizations to promote alternative methods. 2. **Unilever** - **Alternative Methods:** Unilever uses in vitro and in silico methods, including computer modeling and cell-based assays. - **Notable Findings/Successes:** Unilever has developed a non-animal approach for assessing skin sensitization, which has been accepted by regulatory bodies. - **Public Statements:** Unilever has a clear policy against animal testing and actively supports the development of alternative methods. 3. **Procter & Gamble (P&G)** - **Alternative Methods:** P&G uses in vitro and in silico methods, including organ-on-a-chip technology. - **Notable Findings/Successes:** P&G has developed alternative methods for skin and eye irritation testing that have been accepted by regulatory authorities. - **Public Statements:** P&G has publicly committed to reducing and eventually eliminating animal testing. 4. **Givaudan** - **Alternative Methods:** Givaudan uses in vitro methods and has developed a non-animal testing strategy for fragrance safety assessment. - **Notable Findings/Successes:** Givaudan has successfully validated several in vitro methods for fragrance safety. - **Public Statements:** Givaudan has a policy to reduce and replace animal testing wherever possible. # Universities 1. **Johns Hopkins University** - **Alternative Methods:** The Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins promotes the use of in vitro methods, computational toxicology, and organ-on-a-chip technology. - **Notable Findings/Successes:** CAAT has been instrumental in developing and validating numerous alternative methods. - **Public Statements:** CAAT actively promotes the Three Rs (Replacement, Reduction, and Refinement) and works with industry and regulatory bodies to advance alternative methods. 2. **University of California, Berkeley** - **Alternative Methods:** UC Berkeley researchers use in vitro models, including organoids and microfluidic systems. - **Notable Findings/Successes:** Researchers have developed organ-on-a-chip models for drug testing and toxicology. - **Public Statements:** UC Berkeley researchers have published numerous papers advocating for the use of alternative methods. 3. **University of Nottingham** - **Alternative Methods:** The University of Nottingham uses in vitro methods and computational modeling. - **Notable Findings/Successes:** Researchers have developed in vitro models for neurotoxicity and skin sensitization testing. - **Public Statements:** The university has a strong commitment to the Three Rs and actively promotes alternative methods. # Pending Legislations and Global Initiatives 1. **European Union (EU)** - **Legislation:** The EU Cosmetics Regulation (Regulation (EC) No 1223/2009) prohibits animal testing for cosmetics and their ingredients. - **Initiatives:** The EU is actively funding research into alternative methods through programs like Horizon 2020 and Horizon Europe. 2. **United States** - **Legislation:** The Humane Cosmetics Act, if passed, would prohibit animal testing for cosmetics in the U.S. - **Initiatives:** The Environmental Protection Agency (EPA) has committed to reducing animal testing by 2035 and is actively promoting alternative methods. 3. **International Collaborations** - **Initiatives:** The International Cooperation on Alternative Test Methods (ICATM) brings together regulatory bodies from the U.S., EU, Japan, and Canada to promote the development and validation of alternative methods. This list should provide a good starting point for your report. For the most accurate and up-to-date information, you may want to visit the websites of these organizations and look for their latest publications and statements.

answer:To answer this question, I need to carefully consider the requirements of drafting a detailed casting call notice for an independent filmmaker's dramatic period piece set in the 1920s. Let me think about this step by step. First, I should outline the project itself, including its title, genre, setting, and union status. This information is crucial for attracting the right talent and setting the tone for the casting call. Wait, let me break it down - what are the essential elements that need to be included in this introduction? The project title, genre, and setting are straightforward, but I also need to consider the union status, as this can affect the type of talent that responds to the call. Now, let's move on to the project dates. This includes pre-production, production, and post-production dates, which will give potential cast members an idea of the time commitment required. I should also include a brief synopsis of the film's storyline, themes, and vision to help actors understand the context of the roles they're auditioning for. Let me think about how to condense this information into a concise yet informative summary. Next, I need to describe the specific roles that are being cast. This includes the character's name, age range, and ethnicity, as well as a brief description of their background, personality, and role in the story. I should also outline the desired qualities and skills for each character, such as acting experience, accents, or specific skills like dancing or singing. Let me consider how to make these descriptions detailed yet concise, to ensure that actors can quickly determine which roles they're suitable for. For the submission instructions, I should provide clear guidelines on what materials are required, such as headshots, resumes, and self-taped audition monologues. I also need to specify the deadline for submissions and the dates for in-person or virtual auditions. Wait, let me check - are there any specific requirements for the self-taped auditions, such as a maximum length or specific scenes to perform? Now, let's think about where to promote the casting call to reach a wide and diverse pool of talent. There are several online platforms that can be utilized, such as Backstage, Casting Networks, Mandy, and Actors Access. I should also consider Facebook Groups for local actors and filmmakers, as well as subreddits like r/acting and r/filmmakers. Let me think about how to effectively utilize these platforms to reach the target audience. In addition to online promotion, I should also consider local venues where the casting call can be advertised. This could include local acting schools and workshops, community theaters and playhouses, universities and colleges with theater or film programs, and local film commissions and arts councils. I might also consider posting flyers in public areas like cafes, libraries, and community centers. Let me think about how to maximize the visibility of the casting call in these local venues. Finally, I should provide some advice on conducting efficient and respectful auditions. This includes preparing for the auditions by reading the script and understanding the characters, respecting the actors' time, and creating a comfortable environment. I should also consider recording auditions with the actors' consent, to allow for later review and comparison. Let me think about how to ensure a positive experience for all involved, while also maintaining a professional and respectful atmosphere. After careful consideration, I can now draft a detailed casting call notice that includes all the necessary information and guidelines. Here's the refined answer: **Casting Call Notice** **Project Title:** [Your Film Title] **Genre:** Drama, Period Piece **Setting:** 1920s **Union Status:** [Non-Union/Union] **Project Dates:** - Pre-production: [Start Date] - [End Date] - Production: [Start Date] - [End Date] - Post-production: [Start Date] - [End Date] **Synopsis:** [Briefly describe your film's storyline, themes, and vision, ensuring to capture the essence of the project in a concise manner.] **Roles:** 1. **[Character Name]** (Late 20s, Any Ethnicity) - *Description:* [Briefly describe the character's background, personality, and role in the story, highlighting key traits and characteristics.] - *Desired Qualities & Skills:* Strong dramatic acting skills, ability to portray emotional depth, and proficiency in [any required accents or languages]. [List any specific skills, like dancing, singing, or playing an instrument, if applicable.] 2. **[Character Name]** (Early 30s, Any Ethnicity) - *Description:* [Briefly describe the character's background, personality, and role in the story, focusing on the unique aspects of the character.] - *Desired Qualities & Skills:* Charismatic with strong acting skills, ability to portray a [character's specific traits], and proficiency in [any required accents or languages]. 3. **[Character Name]** (Mid 40s, Any Ethnicity) - *Description:* [Briefly describe the character's background, personality, and role in the story, emphasizing the character's significance in the plot.] - *Desired Qualities & Skills:* Experienced actor with strong dramatic chops, ability to portray [character's specific traits], and proficiency in [any required accents or languages]. 4. **[Character Name]** (Early 50s, Any Ethnicity) - *Description:* [Briefly describe the character's background, personality, and role in the story, highlighting the character's impact on the narrative.] - *Desired Qualities & Skills:* Seasoned actor with strong presence, ability to portray [character's specific traits], and proficiency in [any required accents or languages]. **Submission Instructions:** Please submit your headshot, resume, and a self-taped audition monologue (max 2 minutes) to [Your Email Address]. Include the role you're auditioning for in the subject line. For the self-taped audition, please prepare a monologue that showcases your range and ability to portray the character's emotional depth. **Deadline:** [Submission Deadline] **Audition Dates:** - In-person Auditions: [Date] at [Location] - Virtual Auditions: [Date] via [Platform] **Online Platforms for Promotion:** 1. Backstage (www.backstage.com) 2. Casting Networks (www.castingnetworks.com) 3. Mandy (www.mandy.com) 4. Actors Access (www.actorsaccess.com) 5. Facebook Groups for local actors and filmmakers 6. Reddit: r/acting, r/filmmakers, and local subreddits **Local Venues for Promotion:** 1. Local acting schools and workshops 2. Community theaters and playhouses 3. Universities and colleges with theater/film programs 4. Local film commissions and arts councils 5. Cafes, libraries, and community centers with public bulletin boards **Audition Advice:** 1. **Prepare:** Read the script, understand the character, and prepare scenes for the audition. Research the era and setting to ensure authenticity in your performance. 2. **Respect Time:** Be punctual and respect everyone's time. Plan to arrive early to complete any necessary paperwork and to compose yourself before the audition. 3. **Create a Comfortable Environment:** Be welcoming, introduce yourself, and put actors at ease. Ensure the audition space is comfortable and free from distractions. 4. **Provide Context:** Give a brief overview of the project and the character they're auditioning for. This will help the actors understand the context of the scene and the character's role in the story. 5. **Record Auditions:** With the actor's consent, record auditions for later review. This will allow you to compare performances and make informed decisions. 6. **Be Respectful:** Show appreciation for their effort, and notify actors of your decision promptly. Provide constructive feedback when possible, to help them grow and improve. 7. **Safety First:** Ensure a safe and comfortable audition space, adhering to any necessary health guidelines. This includes maintaining a clean environment, providing necessary accommodations, and being mindful of actors' boundaries and comfort levels. By following these guidelines and considering the unique aspects of each role and the project as a whole, you can ensure a successful and respectful casting process. Good luck with your film project!

answer:To answer this, let me think about how to design and outline a feature for a language tool website that allows users to find not just rhymes, but near-rhymes and assonance matches for a given word, considering various pronunciations based on region and allowing users to filter results by syllable count and stress pattern. First, I need to break down the requirements - we're looking to create a feature that's quite complex, involving phonetic matching, regional pronunciations, and user-specific data storage. Let me start by tackling the core functionalities. The feature should allow users to search for rhymes, near-rhymes, and assonance matches. This means we need a robust phonetic matching algorithm or library that can handle these tasks efficiently. Wait, let me check what options are available for phonetic matching. Upon reviewing, I found that the CMU Pronouncing Dictionary could be a great resource, providing comprehensive phonetic transcriptions of words. Additionally, libraries like FuzzyWuzzy for fuzzy string matching and the Natural Language Toolkit (NLTK) for linguistic processing could be invaluable. Now, let's consider the regional pronunciations aspect. We need to ensure our feature accounts for different pronunciations based on the user's region. This could involve integrating with APIs that provide regional pronunciations or using region-specific phonetic dictionaries. Filtering options are also crucial - users should be able to filter results by syllable count and stress pattern. To achieve this, we'll need to implement algorithms that can accurately count syllables and identify stress patterns from phonetic transcriptions. Another important aspect is user accounts and word lists. Users should be able to create accounts, save their word lists, and share them securely with others. This implies we need a secure user authentication system, possibly using OAuth or JWT, and a relational database like PostgreSQL to store user data, ensuring encryption for sensitive information. Let me think about the security measures we need to implement. Secure login mechanisms with hashed passwords, HTTPS for encrypting data in transit, and encryption for data at rest are essential. We should also ensure that users can only access their own word lists unless shared, and implement role-based access control. Now, optimizing for performance and user experience is key. We can use caching mechanisms like Redis to store frequently accessed data, index phonetic data in the database for faster search queries, and implement asynchronous processing for large-scale data tasks. A user-friendly interface with real-time feedback and suggestions, along with load balancing and scalability using cloud services, will be vital for a smooth user experience. Finally, let's not forget about user experience enhancements. Real-time suggestions, interactive filters, visual feedback for syllable count and stress patterns, and a feedback mechanism for users to report incorrect results or suggest improvements will make the feature more engaging and useful. After considering all these aspects, I believe we can design a comprehensive and engaging feature for the language tool website. The Advanced Rhyme and Assonance Finder will not only provide users with accurate rhymes, near-rhymes, and assonance matches but also offer a personalized and interactive experience, enhancing the overall usability and appeal of the website. To summarize, the key components of this feature include: 1. **Core Functionalities**: Implementing rhyme, near-rhyme, and assonance search with regional pronunciation support, filtering by syllable count and stress pattern, and user account management for saving and sharing word lists. 2. **Technical Implementation**: Utilizing the CMU Pronouncing Dictionary, FuzzyWuzzy, and NLTK for phonetic matching, integrating region-specific pronunciations, and employing secure user authentication and data storage practices. 3. **Security Measures**: Ensuring secure login, data encryption, access control, and user privacy. 4. **Optimization**: Implementing caching, indexing, asynchronous processing, and a scalable architecture to ensure high performance and a smooth user experience. 5. **User Experience Enhancements**: Incorporating real-time suggestions, interactive filters, visual feedback, and a user feedback mechanism to make the feature engaging and user-friendly. By carefully considering each of these components and implementing them thoughtfully, we can create a powerful and engaging Advanced Rhyme and Assonance Finder feature for the language tool website.

answer:To answer this, I need to draft a comprehensive section for the academic integrity policy at Humber College that tackles contract cheating and the use of unauthorized online services or platforms. Let me think about this carefully. This means I need to address the evolving digital landscape and remote learning environments, ensuring the policy is clear, effective, and educational for both students and faculty. Wait, let me break this down first - what does it really mean to address contract cheating and unauthorized online services? It means I need to provide clear definitions, examples of prohibited behaviors, potential consequences, and preventive measures to educate the college community. Let me check the key components I need to include. First, I'll tackle the definitions. Let me think... Contract cheating refers to the act of outsourcing academic work to third parties, whether paid or unpaid, and submitting it as one's own. This includes, but is not limited to, essay mills, tutoring services, or peers. Unauthorized online services or platforms, on the other hand, are websites, applications, or tools that facilitate academic dishonesty, such as essay mills, file-sharing platforms for test banks, or services that complete assignments on behalf of students. Now, let's move on to prohibited behaviors. Students must not purchase, commission, or use work from essay mills, tutoring services, or other third parties and submit it as their own. They must not share, sell, or distribute academic work to or through unauthorized online services or platforms. Additionally, they must not use these services to complete assignments, take exams, or gain an unfair advantage. Nor should they collude with others to engage in contract cheating or use of unauthorized online services. Examples of prohibited behaviors include buying essays or assignments online, paying someone to complete an exam or quiz, sharing test banks or exam questions on file-sharing platforms, and using unauthorized online tools to generate or paraphrase content for assignments. Next, I need to consider the potential consequences for violating this policy. Let me think... Violations may result in disciplinary actions, up to and including failure on the assignment or course, suspension or expulsion from the college, notation of academic misconduct on the student's transcript, and loss of access to college facilities and services. Wait, I should also emphasize the importance of preventive measures. For students, this means understanding and adhering to the academic integrity policy, seeking help from college-approved tutoring services and resources, properly citing all sources to avoid plagiarism, and reporting suspected academic misconduct to faculty or college administration. For faculty, it involves designing assessments that discourage contract cheating, such as personalized assignments or in-class exams, using plagiarism detection tools and other technologies to verify the authenticity of student work, educating students on proper citation practices and the consequences of academic misconduct, and reporting suspected academic misconduct to the college administration. Now, let's see... To promote a culture of academic integrity, I should suggest proactive strategies. This could include developing workshops and seminars on academic integrity, proper citation, and responsible conduct of research, encouraging open dialogue about academic integrity in classrooms and college events, and recognizing and rewarding students, faculty, and staff who exemplify academic integrity. Additionally, providing resources such as a comprehensive academic integrity website, access to college-approved tutoring services, writing centers, and libraries, and offering training and support for faculty on effective assessment design and the use of technologies to deter academic misconduct would be beneficial. Finally, I need to consider the review and update process for this policy. Let me think... This policy should be reviewed annually and updated as necessary to address the evolving digital landscape and remote learning environments. Input from students, faculty, and staff should be sought to ensure the policy remains relevant and effective. By following this comprehensive approach, the Humber College community can foster a learning environment that values honesty, responsibility, and fairness, and effectively tackles the issues of contract cheating and unauthorized online services or platforms. Fantastic! After all these considerations, I can confidently say that the draft for the academic integrity policy section on contract cheating and unauthorized online services or platforms is comprehensive and addresses all the necessary components. Here is the detailed draft: **Academic Integrity Policy: Contract Cheating and Unauthorized Online Services or Platforms** **1. Definitions** - **Contract Cheating**: The act of outsourcing academic work to third parties, whether paid or unpaid, including but not limited to essay mills, tutoring services, or peers, and submitting it as one's own. - **Unauthorized Online Services or Platforms**: Websites, applications, or online tools that facilitate academic dishonesty, such as essay mills, file-sharing platforms for test banks, or services that complete assignments on behalf of students. **2. Prohibited Behaviors** Students must not: - Purchase, commission, or use work from essay mills, tutoring services, or other third parties and submit it as their own. - Share, sell, or distribute academic work to or through unauthorized online services or platforms. - Use unauthorized online services or platforms to complete assignments, take exams, or gain unfair advantage. - Collude with others to engage in contract cheating or use of unauthorized online services. Examples of prohibited behaviors include, but are not limited to: - Buying essays or assignments online. - Paying someone to complete an exam or quiz. - Sharing test banks or exam questions on file-sharing platforms. - Using unauthorized online tools to generate or paraphrase content for assignments. **3. Potential Consequences** Violations of this policy may result in disciplinary actions, up to and including: - Failure on the assignment or course. - Suspension or expulsion from the college. - Notation of academic misconduct on the student's transcript. - Loss of access to college facilities and services. **4. Preventive Measures** **For Students:** - Understand and adhere to the academic integrity policy. - Seek help from college-approved tutoring services and resources. - Properly cite all sources and avoid plagiarism. - Report suspected academic misconduct to faculty or college administration. **For Faculty:** - Design assessments that discourage contract cheating, such as personalized assignments or in-class exams. - Use plagiarism detection tools and other technologies to verify the authenticity of student work. - Educate students on proper citation practices and the consequences of academic misconduct. - Report suspected academic misconduct to the college administration. **5. Promoting a Culture of Academic Integrity** **Proactive Strategies:** - Develop workshops and seminars on academic integrity, proper citation, and responsible conduct of research. - Encourage open dialogue about academic integrity in classrooms and college events. - Recognize and reward students, faculty, and staff who exemplify academic integrity. **Resources:** - Establish a comprehensive academic integrity website with resources for students and faculty. - Provide access to college-approved tutoring services, writing centers, and libraries. - Offer training and support for faculty on effective assessment design and the use of technologies to deter academic misconduct. **6. Review and Updates** This policy will be reviewed annually and updated as necessary to address the evolving digital landscape and remote learning environments. Input from students, faculty, and staff will be sought to ensure the policy remains relevant and effective. By adhering to this policy and promoting a culture of academic integrity, the Humber College community fosters a learning environment that values honesty, responsibility, and fairness.